Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes

Brian Mautz, Martin I Lind & Alexei A Maklakov
Abstract Dietary restriction (DR) is a well-established intervention to extend lifespan across taxa. Recent studies suggest that DR-driven lifespan extension can be cost-free, calling into question a central tenant of the evolutionary theory of aging. Nevertheless, boosting parental longevity can reduce offspring fitness. Such intergenerational trade-offs are often ignored but can account for the “missing costs” of longevity. Here, we use the nematode Caenorhabditis remanei to test for effects of DR by fasting on fitness...
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