Extracellular matrix protein signature of recurrent spontaneous cervical artery dissection

Lukas Mayer, Raimund Pechlaner, Javier Barallobre-Barreiro, Christian Boehme, Thomas Toell, Marc Lynch, Xiaoke Yin, Johann Willeit, Elke Ruth Gizewski, Paul Perco, Gudrun Ratzinger, Stefan Kiechl, Manuel Mayr & Michael Knoflach
Objective To assess whether connective tissue disorder is evident in patients with spontaneous cervical artery dissection and therefore identify patients at risk of recurrence using a cutting-edge quantitative proteomics approach. Methods In the ReSect-study all patients with spontaneous cervical artery dissection treated at the Innsbruck University Hospital since 1996 were invited to attend a standardized clinical follow-up examination. Protein abundance in skin punch biopsies (n=50) was evaluated by a cutting-edge quantitative proteomics approach (liquid chromatography-mass...
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