CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway

Laia Montoliu Gaya, Daniel Tietze, Debora Kaminski, Ekaterina Mirgorodskaya, Alesia A Tietze & Fredrik Sterky
Neurexins are presynaptic adhesion molecules that shape the molecular composition of synapses. Diversification of neurexins in numerous isoforms is believed to confer synapse-specific properties by engaging with distinct ligands. For example, a subset of neurexin molecules carry a heparan sulfate (HS) glycosaminoglycan that controls ligand binding, but how this posttranslational modification is controlled is not known. Here, we observe that CA10, a ligand to neurexin in the secretory pathway, regulates neurexin-HS formation. CA10 is exclusively...
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