Single-synapse analyses of Alzheimer’s disease implicate pathologic tau, DJ1, CD47, and ApoE

Thanaphong Phongpreecha, Chandresh Gajera, Candace Liu, Kausalia Vijayaragavan, Alan Chang, Martin Becker, Ramin Fallahzadeh, Rosemary Fernandez, Nadia Postupna, Emily Sherfield, Dmitry Tebaykin, Caitlin Latimer, Carol Shively, Thomas Register, Suzanne Craft, Kathleen Montine, Edward Fox, Kathleen Poston, C. Dirk Keene, Michael Angelo, Sean Bendall, Nima Aghaeepour & Thomas Montine
Synaptic molecular characterization is limited for Alzheimer’s disease (AD). Our newly invented mass cytometry-based method, Synaptometry by Time of Flight (SynTOF), was used to measure 38 antibody probes in approximately 17 million single-synapse events from human brains without pathologic change or with pure AD or Lewy body disease (LBD), non-human primates (NHP), and PS/APP mice. Synaptic molecular integrity in humans and NHP was similar. Although not detected in human synapses, Aβ was in PS/APP mice...
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