Data from: 11C-PK11195-PET brain imaging of the mitochondrial translocator protein in mitochondrial disease

Jelle Van Den Ameele, Young T. Hong, Roido Manavaki, Antonina Kouli, Heather Biggs, Zoe McIntyre, Rita Horvath, Patrick Yu-Wai-Man, Evan Reid, Caroline H. Williams-Gray, Edward T. Bullmore, Franklin I. Aigbirhio, Tim D. Fryer & Patrick F. Chinnery
Objective: To explore the possibilities of radioligands against the mitochondrial outer membrane protein TSPO as biomarkers for mitochondrial disease, we performed positron emission tomography (PET)-MR brain imaging with [11C]PK11195 in 14 patients with genetically confirmed mitochondrial disease and 33 matched controls. Methods: A case-control study of PET-MR imaging with the TSPO radioligand [11C]PK11195. Results: 46% of symptomatic patients had volumes of abnormal radiotracer binding greater than the 95th percentile in controls. [11C]PK11195 binding was generally...
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