Data for: Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

Peter Schuette, Weisheng Wang, Mimi La-Vu, Brooke Tobias, Marta Ceko, Philip Kragel, Fernando Reis, Shiyu Ji, Megha Sehgal, Sandra Maesta-Pereira, Meghmik Chakerian, Alcino Silva, Newton Canteras, Tor Wager, Jonathan Kao & Avishek Adhikari
Escape from threats has paramount importance for survival. However, it is unknown if a single circuit controls escape from innate and conditioned threats. The hypothalamic dorsal premammillary nucleus (PMd) may control escape, as it is strongly activated by escape-inducing threats and projects to the region most implicated in escape, the dorsolateral periaqueductal gray (dlPAG). We show that in mice cholecystokinin (cck)-expressing PMd cells are activated during escape, but not other defensive behaviors. PMd-cck ensemble activity...
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