4.2.6 Comparison of LabelFree ACh Image Sensors Based on CCD and LAPS

Shoko Takenaga, Kazuaki Sawada, Carl Frederik Werner & Michael J. Schöning
Semiconductor-based chemical image sensors, like the pH-image sensor based on a charge-coupled device (CCD) or the light-addressable potentiometric sensor (LAPS), are becoming a powerful tool for label-free imaging of biological phenomena. We have proposed a polyion-based enzymatic membrane to develop an acetylcholine (ACh)-image sensor for neural cell activity observations. In this study, a CCD-type ACh image sensor and a LAPStype ACh image sensor were fabricated and the prospect of both sensors was clarified by making...