CuO nanowires (NWs) based sensors were fabricated and characterized. Cuo NWs were synthesized by thermal oxidation and deposited onto gold electrodes. The sensing layer was morphologically characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showing a monocrystalline structure for CuO NWs. At room temperature these sensors exhibited a non-linear I-V response and showed sensitivity to different concentrations of ethanol. Results are important for low cost and low power consumption gas sensor fabrication.