P2.2.3 Label free immune assay using terahertz chemical microscope

Toshihiko Kiwa, Akira Tenma, Kenji Sakai & Keiji Tsukada
High sensitivity and throughput analysis of the interactions of proteins, label-free detection of antibodyantigen bindings are demanded. In group, a terahertz chemical microscope (TCM) has been proposed and developed to visualize the distribution of the antibody-antigen bindings on the silicon based sensing plate without any labels and/or markers on the antibody. As the first demonstration of the label free immune assay, the mouse immunoglobulin G (IgG) was immobilized on the half part of the sensing...