P3.9 - Measuring System and Method Eliminating Drifts and Parasitic Influences for Cantilever Based Bio-Sensors

Gencho Minchev, Tatiana Mincheva & Vlado Stavrov
The most natural and universal approach for identification of nano-sized biological objects (macromolecules, molecular complexes, viruses, bacterial spores, etc.) is to immobilize them with respective antibodies on cantilever surface and then to measure the sensor mass change. Difficulties arise due to the ultra small magnitude of these changes. An added to the cantilever mass could be registered as a change in deflection or a shift in resonance frequency. Using only one cantilever as an ultrasensitive...