Inflammation And Atherothrombosis: The Beginning Of The End Of A Hypothesis

Adeel Jamil, Umer Jamil, Sunny Kumar, Muhammad Akrmah, Eiman Ghaffarpasand & Gerald Chi
Abstract: The inflammatory hypothesis for atherothrombosis posits that inflammation drives the development of atherosclerotic plaque and its progression to thrombosis. Empirical data have suggested the relation of inflammation to the Virchow’s triad: endothelial injury, blood stasis, and hypercoagulable state. Evidence from clinical studies also pointed to a potential benefit in thrombotic risk reduction from inhibiting inflammation. Until recently, interleukin-1β blockade with canakinumab has been investigated for preventing recurrent cardiovascular events among patients with prior myocardial...
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