High-Density Lipoprotein-Targeted Therapy For Coronary Heart Disease: Is The Hdl Hypothesis Operational Or Defunct?

Gerald Chi, Zahra Karimi, , , , & Arzu Kalayci
Abstract: Supported by evidence from basic science, clinical, and epidemiological studies, the high-density lipoprotein (HDL) hypothesis posits that reduction in HDL levels may accelerate the development of coronary heart disease (CHD). HDL may also exert cardiovascular protection via anti- oxidative, anti-thrombotic, anti-inflammatory, and anti-apoptotic properties. However, controversial results from clinical trials involving HDL- raising interventions have cast doubts on the validity of HDL hypothesis. The coevolution of HDL physiology and CHD pathogenesis has prompted the...
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