Now published in Nature Plants, 5:457-458 Pathogen perception triggers a monomeric NLR plant immune receptor to form a pentameric wheel-like complex termed a resistosome, with the N-terminal ahelices forming a funnel-shaped structure that may perturb plasma membrane integrity to cause hypersensitive cell death. Nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular receptors that detect pathogen molecules and activate a robust immune response that includes the hypersensitive response (HR) cell death in plants. Although plant NLRs are...