Design, One-pot Synthesis and Biological Evaluation of Imidazo[2,1-b] [1,3,4] Thiadiazole Derivatives for their Anti- Tubercular and Anti-Fungal Activity

Mukesh Bugalia, , , Mahesh Jhajharia & Prashant Sharma
Abstract— In the present designed work, we have synthesized imidazo[2,1-b][1,3,4]thiadiazole derivatives (6a1-a6 to 6d1-d6) by reaction of compound 3 with appropriate α-haloaryl ketones produce substituted imidazo thiadiazole derivatives (4a-d). In the next step, these compounds (4a–d) undergoes the Vilsmeier reaction to introduce formyl group on the substituted arylimidazo[2,1-b][1,3,4]thiadiazole derivatives to form carbaldehyde derivatives (5a–d) and finally in the last step of the reaction for the synthesis of designed molecules, a one-pot synthetic procedure was used....
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