Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.

Valerie O'Donnell, Nils H Schebb, Ginger L Milne, Michael P Murphy, Christopher P Thomas, Dieter Steinhilber, Stacy G Wendell, Hartmut Kühn, , Ian Blair, Robert C Murphy, Bruce A Freeman, Alan R Brash & Garret FitzGerald
Specialized pro-resolving mediators (SPM) derived from oxygenation of long chain polyunsaturated fatty acids (PUFA) were originally described by Serhan and colleagues and have been proposed as mediators of inflammation resolution. Families of SPM described in the literature include lipoxins, resolvins, maresins, protectins and their peptide conjugates. In this article Gomez and co-authors report that levels of plasma SPM from patients with early rheumatoid arthritis predict response to biologic therapy after 6 months. SPM were measured...
1 citation reported since publication in 2021.
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