Stromal Stem Cells From Parathyroid Glands Of Patients With Secondary Hyperparathyroidism Demonstrate Higher Telomerase Activity And Osteogenic Differentiation Ability Than Normal Bone Marrow Derived Stromal Stem Cells

Erdal Karaöz, Soykan Arıkan, Ayça Aksoy, Zehra Seda Ünal, Mine Adaş, Gökhan Adaş & Gökhan Duruksu
Aims: The aim of this study was to isolate and extensively characterize parathyroid gland stem cells (PT-SCs) from secondary hyperparathyroidism cases. For this purpose, proliferation capacity, phenotypic properties, differentiation characteristics and gene expression profiles were analyzed and compared with mesenchymal stem cells from bone marrow (BM-MSCs) of the human. Methods: Stem cells isolated from PT and BM were analyzed by flow cytometry, RTPCR, Real Time-PCR, and immunocytochemistry. Both cell lines were directionally differentiated towards adipogenic,...
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