Characterisation of Hybrid Lipid-Polymer Nanoparticles

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Hybrid lipid-polymer nanoparticles have demonstrated potential as drug delivery vehicles. The current proposal aims to use small angle neutron scattering (SANS) in combination with contrast variation to determine the detailed molecular structure of the drug-containing hybrid lipid-polymer nanoparticles, as well as their component lipid vesicles and polymeric nanoparticles. SANS coupled with contrast variation will allow us to establish precisely how much lipid is required to reproducibly and reliably coat the various sized polymeric NPs without...
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