Do cardiolipins play a role for the mode of action of antimicrobial peptides? A study using free floating lipid model membranes

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Antimicrobial peptides (AMPs), also called host defense peptides, are part of the innate immune system of essentially all species, from bacteria themselves to mammals to protect against bacterial pathogens. Although the exact microscopic mechanism(s) is still debated, this chemical structure allows them to target bacterial cell membranes which have net negative charge, selectively. One hypotheses of the mode of action is that AMPs interacts with cardiolipins (CL), and important anionic lipid present in bacterial membranes...
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