Discriminating the conformation of G4 DNA by SANS.

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Guanine-­rich DNA sequences are prone to fold into stable helical four­-stranded structures called G­quadruplexes (G4). These systems have drawn the attention of a number of scientists in both basic and applied research fields, including structural biophysics, cancer biology, novel therapeutics through to nanotechnology. And most importantly, G4s have been proposed as selective and effective therapeutic anticancer targets. However, the intrinsic polymorphism of G4s makes very challenging the prediction of the architectural folds encoded in guanine-rich...
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