Full Length 3D Monomer Structure of Human Tumor Suppressor Protein p53 Using Homology Based Approach Combined with a Refinement process

p53 is a very important Tumor Suppressor Protein that plays key roles in many cellular mechanisms thus preventing the development of cancers in humans. Its gene, TP53 is positioned on chromosome 17p13 and encodes a 53 kilodalton nucleophosphoprotein which is a transcription factor with a central role in cell cycle regulation. However, mutations in this protein lead to various types of human cancers and it is estimated that more than 50% of human cancers are...
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