PGE2 docked Rat Prostanoid E2 Receptor Subtype 4 (rEP4)

The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and promote development of therapeutics for bone healing, heart failure, and other receptor associated conditions. Homology models were generated by threading for human and rat EP4 receptors using the RaptorX server. These models were fit to an implicit membrane using the PPM server and...
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