Model of G-alpha-i3 bound to the GIV GBA-motif

The activation of heterotrimeric G proteins is typically achieved by guanine nucleotide exchange factor (GEF) proteins that facilitate the exchange of GDP for GTP on G-alpha subunits. While this exchange activity is typically performed by G protein-coupled receptors (GPCRs), cytosolic non-receptor type GEFs have been more recently described as G-alpha activators. A subset of the described non-receptor GEFs contain a Galpha-Binding and Activating (GBA) motif. This short, evolutionarily conserved motif is known to confer nucleotide...
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