Complex between HIV-1 integrase and human mitochondrial lysyl-tRNA synthetase

Replication of human immunodeficiency virus type 1 (HIV-1) requires the packaging of tRNALys,3 from the host cell into the new viral particles. The GagPol viral polyprotein precursor associates with mitochondrial lysyl-tRNA synthetase in a complex with tRNALys, an essential step of the viral life cycle to capture the primer RNA necessary to initiate reverse transcription in the virions. The C-terminal integrase moiety of GagPol is known to be essential for its association with GagPol. In...
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