Multidrug transporter MexY of Pseudomonas aeruginosa

Secondary multidrug transporters of the resistance-nodulation-cell division (RND) superfamily contribute crucially to antibiotic resistance in Gram-negative bacteria. Compared to the most studied transporter AcrB of E. coli, little is known about the molecular determinants of distinct polyspecificities of the most important RND transporters MexB and MexY of Pseudomonas aeruginosa. The absence of an experimental structure of MexY and the availability of only one structure of MexB bound to compounds (the ABI-PP inhibitor D13-9001) have made...
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