Factor VIII/von Willebrand Factor Complex

Paul Clinton Spiegel
Blood coagulation factor VIII forms a tight complex with von Willebrand Factor in circulation, which protects factor VIII from proteolytic degradation and increases its half-life. The region of von Willebrand Factor that binds to factor VIII is the N-terminal TIL'E' domain. In this model, we combined two structures: the 3.2 Å X-ray crystal structure of factor VIII and the NMR-determined structure of TIL'E'. The putative complex was computationally docked together with RosettaDock as part of...
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