Integrating mechanism-based screening paradigm into homology and de novo modeling exemplified by Mycobacterium Tuberculosis 30S ribosomal structure and its potential application as a screening target

Motivation: Mycobacterium tuberculosis, the causative agent of the tuberculosis, has infected more than a third of the world’s popula-tion to date. It is known to be substantially aggressive and highly resistant to current drugs that target it. Antibiotics such as viomycin and capreomycin have been shown to bind to functionally important regions of the bacterial ribosome thereby inhibiting the protein synthesis process which subsequently affects the bacterial cell viability. Current methods for studying drug interaction...
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