Assembled fragment compound targeting pre-miR-21

Small molecule fragments containing photoreactive diazirine moieties were screened for binding to the oncogenic non-coding microRNA precursor to miR-21 (pre-miR-21). By assembling a fragment and RNA binding module previously identified, a bioactive ligand was discovered that modulated miR-21 biology in cells. The compound selectively affects an invasive phenotype for triple negative breast cancer cells that is mediated by miR-21 over expression. The de novo model of the compound interacting with the Dicer processing site of...
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