Structural insight on ATP hydrolysis in RecA/triple-stranded DNA nucleofilament

Chantal Prévost
Homologous recombination (HR) is a fundamental process that allows the faithful repair of DNA double strand breaks through the exchange of DNA strands between homologous regions of the genome. In bacteria, the exchange takes place within nucleofilaments of the RecA protein formed on a DNA strand from the damaged region. ATP is hydrolyzed in large quantity during the HR process, yet how exactly hydrolysis influences the DNA strand exchange reaction at the structural level remains...
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