Allosteres to Regulate Neurotransmitter Sulfonation

Catecholamine neurotransmitter levels in the synapses of the brain shape human disposition — cognitive flexibility, aggression, depression, reward seeking… — and manipulating these levels is a major objective of the pharmaceutical industry. Certain transmitters are extensively sulfonated — an inactivating modification catalyzed by human sulfotransferase 1A3 (SULT1A3). To our knowledge, sulfonation as therapeutic means of regulating transmitter activity has not been explored. Here we describe the discovery of a SULT1A3 allosteric site that can be...
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