NS3 MutantM (JFH-1)

To gain an insight into mutation flexibility across sequence space of hepatitis C virus (HCV) genome, we created mutant libraries, differing from the parent sequence as well as each other by using a random mutagenesis approach; the proportion of mutations increased across these libraries with declining template amount or dATP concentration. Replication efficiency of full-genome mutant libraries ranged between 71 and 329 foci forming unit (FFU) per 105 Huh7.5 cells. Mutant libraries with low proportions...
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