Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane

Guillaume Charras, Ana Lisica, Jonathan Fouchard, Julia Duque Lloredo, Manasi Kelkar & Buzz Baum
In growing epithelia, divisions are typically oriented in the epithelial plane to drive tissue expansion. In some organs, divisions are then re-oriented so that they occur perpendicular to the epithelium plane to drive tissue stratification and cell differentiation. When uncontrolled, this switch in orientation can lead to defects in tissue organisation and, in the context of cancer, has been suggested to contribute to metastasis. While much is known about the molecular machinery guiding mitotic spindle...
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