Sex and other host factors influencing urinary tract infection pathogenesis

Patrick D. Olson & David A. Hunstad
Biological sex represents the most important host factor that influences urinary tract infections (UTIs), which are most commonly caused by uropathogenic Escherichia coli (UPEC). UTI susceptibility varies by sex and age throughout the patient lifespan, although the disease disproportionally afflicts women throughout the middle ages. Substantial male patient populations are also affected, and morbidity in complicated UTI is higher in men. This review highlights sex-related discrepancies in the disease, and how sex may influence the...
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