This chapter summarizes our present experience with invasive regimen in BPS/IC therapy. A broad spectrum of interventions including simple endoscopic procedures as well as extensive surgery are performed in this indication. Hydrodistension, fulguration of Hunner’s lesions, sacral neuromodulation and cystectomy may all give significant symptom relief to BPS/IC patients, however, the efficacy is not perfectly predictable. Thus, patient selection is crucial, and our algorithms for precise selection of patients for each procedure still are improvable.
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