Indomethacin Electrospun Nanofibers for Colonic Drug Delivery: Preparation and Characterization

Abbas Akhgari, Zohreh Heshmati & Behzad Sharif Makhmalzadeh
Purpose: The objective of this study was to prepare a suitable form of nanofiber for indomethacin using polymers Eudragit RS100 (ERS) and Eudragit S100 (ES) and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. Methods: Electrospinning process was used for preparation of nanofibers. Different solutions of combinations of ERS, ES and indomethacin in various solvents and different ratios were prepared. The spinning solutions were loaded in 10 mL syringes. The...