Thermoanalytical Investigation of Terazosin Hydrochloride

Ali Kamal Attia & Mona M. Abdel-Moety
Purpose: Thermal analysis (TGA, DTG and DTA) and differential scanning calorimetry (DSC) have been used to study the thermal behavior of terazosin hydrochloride (TER). Methods: Thermogravimetric analysis (TGA/DTG), differential thermal analysis (DTA) and differential scanning calorimetry (DSC) were used to determine the thermal behavior and purity of the used drug. Thermodynamic parameters such as activation energy (E*), enthalpy (H*), entropy (S*) and Gibbs free energy change of the decomposition (G*) were calculated using different kinetic...