High Performance Liquid Chromatographic Analysis of Almotriptan Malate in Bulk and Tablets

Petikam Lavudu, Avula Prameela Rani, Chepuri Divya & Chandra Bala Sekaran
Purpose: A simple RP-HPLC method has been developed and validated for the determination of almotriptan malate (ATM) in bulk and tablets. Methods: Chromatographic separation of ATM was achieved by using a Thermo Scientific C18 column. A Mobile phase containing a mixture of methanol, water and acetic acid (4:8:0.1 v/v) was pumped at the flow rate of 1 mL/min. Detection was performed at 227 nm. According to ICH guidelines, the method was validated. Results: The calibration...