Targeted Fluoromagnetic Nanoparticles for Imaging of Breast Cancer MCF-7 Cells

Mostafa Heidari Majd, Jaleh Barar, Davoud Asgari, Hadi Valizadeh, Mohammad Reza Rashidi, Vala Kafil, Javid Shahbazi & Yadollah Omidi
Purpose: To achieve simultaneous imaging and therapy potentials, targeted fluoromagnetic nanoparticles were synthesized and examined in human breast cancer MCF-7 cells. Methods: Fe3O4 nanoparticles (NPs) were synthesized through thermal decomposition of Fe(acac)3. Then, magnetic nanoparticles (MNPs) modified by dopamine-poly ethylene glycol (PEG)-NH2; finally, half equivalent fluorescein isothiocyanate (FITC) and half equivalent folic acid were conjugated to one equivalent of it. The presence of Fe3O4-DPA-PEG-FA/FITC in the folate receptor (FR) positive MCF-7 cells was determined via...