Gene Therapy, Early Promises, Subsequent Problems, and Recent Breakthroughs

Saeideh Razi Soofiyani, Behzad Baradaran, Farzaneh Lotfipour, Tohid Kazemi & Leila Mohammadnejad
Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissues for clinical applications has been discussed around half a century, but scientist’s ability to manipulate genetic material via recombinant DNA technology made this purpose to reality. Various approaches, such as viral and non-viral vectors and physical methods, have been developed to make gene delivery safer and more efficient. While gene therapy initially conceived as a way to...