GABAB Receptor Blockade Prevents Antiepileptic Action of Ghrelin in the Rat Hippocampus

Zohreh Ataie, Shirin Babri, Mina Ghahramanian Golzar, Hadi Ebrahimi, Fariba Mirzaie & Gisou Mohaddes
Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear. In the present study; we investigated antiepileptic mechanism of ghrelin through GABAB receptors using CGP35348 (selective GABAB receptor antagonist). Methods: Male Wistar rats' hippocampi were bilaterally microinjected with the single dose or 10-day ghrelin (0.3 nmol/μl/side). CGP35348, GABAB receptor antagonist, (12.5 μg/μl/side) or saline injected into the dorsal hippocampus 20 minutes before...