HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction

Elnaz Mosaferi, Jafar Majidi, Mozhdeh Mohammadian, Zohreh Babaloo, Amir Monfaredan & Behzad Baradaran
Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic T lymphocyte. There are some mechanisms that modulate maternal immune responses during pregnancy, in order to make uterus an immune privileged site. This immunosuppression is believed to be mediated, at least partly, by HLA-G, non-classical class I...