Gap Junctions: The Claymore for Cancerous Cells

Masoud Asadi-Khiavi, Hossein Hamzeiy, Sajjad Khani, Ailar Nakhlband & Jaleh Barar
Introduction: Gap junctions play an important role in the cell proliferation in mammalian cells as well as carcinogenesis. However, there are controversial issues about their role in cancer pathogenesis. This study was designed to evaluate genotoxicity and cytotoxicity of Carbenoxolone (CBX) as a prototype of inter-cellular gap junction blocker in MCF7 and BT20 human breast cancer cells. Methods: The MCF7and BT20 human breast cancer cell lines were cultivated, and treated at designated confluency with different...