Barrier Functionality of Porcine and Bovine Brain Capillary Endothelial Cells

Ailar Nakhlband & Yadollah Omidi
Introduction: To date, isolated cell based blood-brain barrier (BBB) models have been widely used for brain drug delivery and targeting, due to their relatively proper bioelectrical and permeability properties. However, primary cultures of brain capillary endothelial cells (BCECs) isolated from different species vary in terms of bioelectrical and permeability properties. Methods: To pursue this, in the current investigation, primary porcine and bovine BCECs (PBCECs and BBCECs, respectively) were isolated and used as an in vitro...