Planning Genomic Study in an Animal Model of Depression: a Preliminary Report

Alireza Farnam, Ali Fakhari, Leila Roshangar, Sajjad Kahni & Sara Farhang
Introduction: Interaction of several genes is responsible for psychiatric diseases such as depression. Despite the numerous microarray studies in this field, findings are controversial and hard to conclude. Methods: Male Wistar rats were randomly selected to receive Chronic Mild Stress model for 4 weeks. Different aspects of depression were measured by forced swimming test, open field trial and sucrose preference tests in the experience group and controls. Results: Sucrose was preferred by 40% of CMS...