Electrochemical Impedance Spectroscopic Sensing of Methamphetamine by a Specific Aptamer

Mohsen Ebrahimi, Mohammad Johari-Ahar, Hossein Hamzeiy, Jaleh Barar, Omid Mashinchian & Yadollah Omidi
Introduction: Electrochemical impedance spectroscopy (EIS) is a simple and highly sensitive technique that can be used for evaluation of the aptamer-target interaction even in a label-free approach. Methods: To pursue the effectiveness of EIS, in the current study, the folding properties of specific aptamer for methamphetamine (METH) (i.e., aptaMETH) were evaluated in the presence of METH and amphetamine (Amph). Folded and unfolded aptaMETH was mounted on the gold electrode surface and the electron charge transfer...