Comparison of the Analgesic Effect of Diclofenac Sodium-Eudragit® RS100 Solid Dispersion and Nanoparticles Using Formalin Test in the Rats

Khosro Adibkia, Alireza Mohajjel Nayebi, Mohammad Barzegar-Jalali, Siavash Hosseinzadeh, Saeed Ghanbarzadeh & Afshin Shiva
Purpose: In this study the intensity and duration of analgesic effect of diclofenac Na - Eudragit® RS100 solid dispersion and nanoparticles were evaluated by using formalin test in the rats. Methods: The animals received different formulations of diclofenac Na and subsequently 50 µl of formalin solution (2.5%) was injected subcutaneously in the right paws after 1 h, 2 h and 3 h. The paw licking behavior was then evaluated in two phases. A dose of...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.