CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors

Mashael Al-toub, Mohammad Almohawes, Radhakrishnan Vishnubalaji, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem & Nehad M. Alajez
The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e.g., MCF7 breast cancer line, exhibited growth advantage when cultured in the presence of conditioned media (CM)...
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