Predictive value of tyrosine phosphatase receptor gamma for the response to treatment tyrosine kinase inhibitors in chronic myeloid leukemia patients

Mohamed A. Ismail, Marzia Vezzalini, Hisham Morsi, Ahmad Abujaber, Ali Al Sayab, Kodappully Siveen, Mohamed A. Yassin, Maria Monne, Muthanna Samara, Richard Cook, Claudio Sorio, Helmout Modjtahedi & Nader I. Al-Dewik
Protein tyrosine phosphatase receptor gamma (PTPRG) is a member of the receptor-like family protein tyrosine phosphatases and acts as a tumor suppressor gene in different neoplasms. Recent studies reported the down-regulation of PTPRG expression levels in Chronic Myeloid Leukemia disease (CML). In addition, the BCR-ABL1 transcript level is currently a key predictive biomarker of CML response to treatment with Tyrosine Kinase Inhibitors (TKIs). The aim of this study was to employ flow cytometry to monitor...
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