Neutralizing antibodies against SARS-CoV-2 are higher but decline faster in mRNA vaccinees compared to individuals with natural infection

Haissam Abou-Saleh, Bushra Y Abo-Halawa, Salama Younes, Nadin Younes, Duaa W. Al-Sadeq, Farah M Shurrab, Na Liu, Hamda Qotba, Nader Al-Dewik, Ahmed Ismail, Hadi M Yassine, Laith J Abu-Raddad & Gheyath K Nasrallah
Background Waning protection against emerging SARS-CoV-2 variants by pre-existing antibodies elicited because of current vaccination or natural infection is a global concern. Whether this is due to the waning of immunity to SARS-COV-2 remains unclear. Aim We aimed to investigate the dynamics of antibody isotype responses amongst vaccinated naïve (VN) and naturally infected (NI) individuals. Methods We followed up antibody levels in COVID-19 messenger RNA (mRNA)-vaccinated subjects without prior infection (VN, n = 100) in...
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