Bacteriophage lambda overcomes a perturbation in its host‐viral genetic network through mutualism and evolution of life history traits

Animesh Gupta, Anechelle N. Soto, Sarah J. Medina, Katherine L. Petrie & Justin R. Meyer
An important driver of viral evolution is natural selection to optimize the use of their hosts’ genetic network. To learn how viruses respond to this pressure, we disrupted the genetic network of Escherichia coli to inhibit replication of its virus, bacteriophage lambda, and then observed how λ evolved to compensate. We deleted E. coli's dnaJ gene, which lambda uses to initiate DNA replication. Lambda partially restored its ability to reproduce with just two adaptive mutations...
1 citation reported since publication in 2020.
176 views reported since publication in 2020.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?
20 downloads reported since publication in 2020.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?