Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

Michal Krawczyk, Lorena Raquel Rocha, Viet Anh Nguyen Huu, Claudia Palomino La Torre, Qianlan Xu, Mary Jabari, Robert N. Weinreb & Dorota Skowronska-Krawczyk
Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimicks events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset of genes that encode multiple proteins collectively referred to as the senescenceassociated secretory phenotype (SASP). Emerging evidence suggests that the presence of these proinflammatory and matrix-degrading molecules has deleterious effects in a variety of tissues. In the current study, we demonstrated in a transgenic...
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